After losing half their team, the remaining members look for answers as time begins to run out for Ghost Rider.

Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman Registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May…

The team reels from their losses as Hive continues to draw Inhumans to his side; Agents Fitz and Simmons get a lead that could stop the maniacal Inhuman forever.

Coulson and his team race to combat Hive’s control over the Inhumans, as their enemy’s deadly plan for the human race is revealed.

S.H.I.E.L.D. hunts for information on their dangerous new enemy, and a shameful secret from Malick’s past is exposed, threatening to destroy his Hydra legacy.

The S.H.I.E.L.D. team tries to prove that fate is not fixed after Daisy is horrified by a glimpse of the future.