Simone’s wedding day arrives as Jo and Link’s relationship hits a major turning point.

With Levi’s help, a patient celebrates a milestone. Jo processes a difficult diagnosis, and Maggie and Winston decide their future.

Catherine returns to Grey Sloan for a surgical case that makes Lucas and Blue queasy. Amelia treats a possible cancer patient with a family that’s a little too supportive. Owen…

Bailey and Addison take a road trip to volunteer at a family planning center, but a patient’s ectopic pregnancy leads to complications. Elsewhere, the interns play detective about Lucas’ relationship…