When multiple children get sick from lead poisoning, Morgan Edge points the finger at Lena and blames her creation of the lead bomb she made to save National City from…

Kara investigates a secretive new group whose leader, Thomas Coville, has a mysterious connection to Supergirl. Meanwhile, Samantha feels like she’s letting Ruby down, and J’onn confesses an old secret.

Eliza throws Alex and Maggie a wedding shower, which causes Maggie to reach out to her estranged father. Supergirl joins J’onn on a personal mission.

Psi, a thief with psychic powers, attacks National City. Able to immobilize people by tapping into their worst fears, Psi proves a formidable opponent for Supergirl. Meanwhile, James and Lena…

Kara deals with the loss of Mon-El by focusing all her energy on being Supergirl and the mysterious new threat against National City. Alex confesses a secret to Maggie about…