When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie’s fiancé, Andrew, into the…

Coulson’s life or death is the challenge the team finds themselves in, as the wrong decision will cause the destruction of Earth.

Daisy’s future as the destroyer of worlds could take a critical change.

The team must find a way to stop Ruby before the prophesied chain reaction that can destroy the Earth is put into motion.

Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.